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Figure 1.
Figure 1. Structure of the DDX6-C/EDC3-FDF Heterodimer
(A) Domain organization of DDX6 and EDC3. The structured part of
the DDX6 C-terminal domain is shown in gray, with the conserved
helicase motifs in purple. The EDC3-FDF peptide is highlighted
in salmon. Numbers correspond to the human proteins.
(B)
Ribbon diagrams of the complex colored as in (A). Side chains
for the EDC3-FDF and EDC3-FDK motifs and for DDX6-His312 are
shown as sticks.
(C and D) Electrostatic potentials were
mapped onto the respective molecular surface and contoured from
−5 kT/e (red) to +5 kT/e (blue). In (C), EDC3-FDF is
represented as sticks (carbons in yellow, oxygens in red,
nitrogens in blue) on the molecular surface of DDX6-C. (D) shows
the molecular surface of the complex and changes in charge
distribution.
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