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Figure 1.
Crystal structure of the C-terminal pre-IQ-IQ fragment from
the Ca[V]1.2 α[1] subunit. CaM N-lobes/domains are tan; C-lobes
light blue; Ca^2+ ions are gold spheres. Ca[V]1.2 fragments (I
and II) are blue to orange rainbow starting from the N termini
(marked with N); the IQ domain for fragment I is red. Loop
regions, the IQ domain for fragment II, and the C-domain of CaM
IV are not seen in the density and are modeled, by analogy with
fragment I and CaM III, as thin light gray lines for reference.
The N- and C-lobes of the extended form of CaMs I and II
bridging the pre-IQ segments are separated by ≈15 Å,
whereas those of CaM III bound to the IQ motif of Ca[V]I
fragment make contacts. Figs. 1 and 2 were made with PyMOL
(www.pymol.org).
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