|
Figure 1.
(a) Erbin-PDZ in complex with a C-terminal peptide
(WETWV[COOH], PDB entry 1N7T, deposited as part of a previous
study). (b) Dvl2-PDZ in complex with C-terminal pep-C1
(WKWYGWF[COOH], K[i] = 0.7  0.2
 M).
(c) Dvl2-PDZ in complex with internal peptide pep-N1
(WKDYGWIDGK, K[i] = 1.2 0.3
M).
(d) Dvl2-PDZ in complex with internal peptide pep-N2
(SGNEVWIDGP). (e) Dvl2-PDZ in complex with internal peptide
pep-N3 (EIVLWSDIP, K[i] = 4.6 2.2
M).
In the left panels, the peptides (shown as sticks) are colored
according to their interactions with subsites on the PDZ domains
(green, site C; orange, site 0; magenta, site -1; blue, site -2;
yellow, site -3; tan, other residues). The right panels show
surface representations of the PDZ domains, with subsites
colored as described for the left panels, and peptide ligands
colored according to atom type (tan, carbon; blue, nitrogen;
red, oxygen). The peptide residues are labeled according to the
subsites they occupy on the PDZ domain.
|
