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Figure 1.
Structure and substrate selection in CDK4/cyclin D3. (A) The
fold of CDK4/cyclin D3 (left side) is compared with that of
CDK2/cyclin A in complex with a substrate peptide (PDB ID code
1QMZ; right side). Important structural and regulatory elements
referred to in the text are indicated on each structure and
correspond to the CDK N-lobe (light gray), the C-helix (cyan),
the CDK C-lobe (yellow), the activation segment (red), and the
cyclin subunit (green). (B) The activity of CDK4/cyclin D3
toward pRb family members highly depends on substrate
recruitment. See Results for details.
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