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Figure 1.
Figure 1. Structure of DnaC[AAA+]
(A) Domain
representation of DnaC. The N-terminal helicase binding region
is colored gray and the central AAA+ domain is shown in red.
Numbers refer to amino acid positions. AAA+ motifs are
highlighted. WA, Walker-A; WB, Walker-B; SI, sensor-I; SII,
sensor-II; ISM, Initiator Specific Motif.
(B) Sequence
alignment of selected DnaC and DnaA homologs. Alignment was
generated by ClustalX (Thompson et al., 1997).
(C) Stereo
view of DnaC[AAA+]. Walker-A and -B motifs are blue and yellow,
respectively. The sensor-I residue is green and the Box VII
helix cyan. ADP and the coordinating magnesium ion (black) are
shown within the ATP binding cleft. An internal disordered
region is shown as a dotted line. This and all other molecular
figures were generated with PyMOL (pymol.sourceforge.net).
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