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Figure 1.
Figure 1: Crystal structure of T. thermophilus argonaute bound
to a 5'-phosphorylated 21-base DNA guide strand. a, Stick
(DNA) and ribbon (Ago) view of the 3.0 Å structure of the
complex. Individual domains and linkers are colour-coded. The
bound 21-base DNA guide strand is coloured red (with phosphorus
atoms in yellow), and can be traced for nucleotides 1 to 11 and
18 to 21, together with phosphates at positions 16 and 17. b,
Corresponding stick (DNA) and electrostatically colour-coded
surface (Ago) view of the complex. c, An alternate stereo view
of the complex from that shown in a. For rotation of c, see
Supplementary Movie 2DLH.
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