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Figure 1.
Figure 1: Averaged 3D structure of the HIV-1 spike in complex
with b12-Fab. a, Perspective view of the surface of the
density map shown at two thresholds; one to include the entire
spike (outer), and another to highlight the Fab and gp120
components (inner). b–d, Front (b, c) and top (d) views of the
map fitted with X-ray coordinates of the complex of the Fab
fragment of b12 (cyan) with gp120 (red, PDB ID, 2NY7); only
gp120 coordinates are shown in c, which is at the inner
threshold. Likely locations of the V1/V2 loop and gp41 regions
are indicated by asterisks in d and the white arrow in b,
respectively. The stumps of the V1/V2 and V3 loop regions are
shown in yellow and green, respectively.
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