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Figure 1.
Figure 1. (A) Alignment of the protein sequences of M7 and
TOP7. Residues identical to the sequence of TOP7 are shaded in
green. Secondary structure elements of M7 are indicated above
the line as  -helix
( ),
 -strand
( ),
regular -turn
(t) or loop (l). Blue triangles mark the position of residues
with greater than 40% occluded surface in TOP7.[7] (B) Ribbon
diagram highlighting the secondary structure elements of the M7
solution structure. The five antiparallel -strands
(A-E) are indicated as cyan arrows, while the two -helices
(I and II) are shown in red/yellow. (C) Backbone trace
superposition of the final 20 energy-minimized M7 conformers
(yellow lines) with the designed structural model (magenta
ribbon).
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