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Figure 1.
Figure 1. 3D Structures of Bromodomains Bound to Acetylated
Histone Peptides
The structures of the
bromodomain/acetylated histone peptide complexes are shown in
three different illustrations: stereoview of the backbone atoms
(N, Cα, and C′) of 25 superimposed NMR structures of the
complexes (left); ribbons representation of the average
minimized NMR structure of the complexes in a similar
orientation, prepared using Pymol (middle); and surface
electrostatic potential representation of the protein with the
peptide in a ball-and-stick depiction (right).
(A–C) The
PCAF bromodomain/H3-K36ac complex.
(D–F) The PCAF
bromodomain/H3-K9ac complex.
(G–I) The CBP
bromodomain/H4-K20ac complex.
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