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Figure 1.
The SAM domains of CNK and HYP interact directly. (A) Domain
architecture of CNK and HYP. CNK is characterized by the
presence of a SAM (sterile α-motif) domain; a CRIC (conserved
region in CNK); a PDZ (PSD-95, ZO-1/2, Dlg-1) domain; and a PH
(pleckstrin homology) domain. HYP contains a single SAM domain.
Indicated protein sizes correspond to the Drosophila members.
(B) Pull-down analysis of GST-dHYP^SAM with hCNK2^SAM. GST and
GST-Vts1^SAM served as controls.
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