|
Figure 1.
Two views of the PD-1/PD-L1 complex. The two single-domain
PD-1 molecules in the asymmetric unit of the crystal are shown
in red (PD-1) and violet (second PD-1). The two-domain PD-L1
molecule is shown in blue. The strands of the two β-sheets of
PD-1 are labeled ABED and A′GFCC′C″. The strands of the
two β-sheets of the PD-L1 V domain are labeled AGFCC′C″ and
BED. Note the tenuous contacts that the second PD-1 makes to
PD-1 and PD-L1, seen best on the right side of the figure.
N-linked glycosylation sites (gold) are at PD-1 residues 49, 58,
74, and 116 and at PD-L1 residue 35. Carbohydrate at any of the
five potential sites is predicted not to interfere with the
formation of the complex. The view at right is after a rotation
of 45° around the vertical axis. The N and C termini are
identified.
|
