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Figure 1.
The unique dimeric ROC GTPase. (A) Stereoview of the
domain-swapped dimer. The two individual monomers are shown in
yellow and green. The GDP-Mg^2+ ligands are shown in
ball-and-stick format. (B) Ribbon representation of a single
monomer. The three head, neck, and body subdomains are
indicated, along with the labeled secondary structures. The
P-loop, G3/Switch II, and G4 and G5 loops are indicated in
orange, pink, red, and cyan, respectively. The disordered G2
loop is shown as a black dotted curve. (C) Surface
representation highlighting the GDP-Mg^2+ binding pocket on the
surface of the dimer that is contributed from both monomers. The
pair of functional units are shown as ROCs1 and ROCs2,
respectively.
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