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Figure 1.
Chemical structures of selected EGFR inhibitors. All
compounds are drawn in a consistent orientation and conformation
that reflects their approximate binding mode in the EGFR kinase.
HKI-272 and EKB-569 are examples of irreversible inhibitors.
Lapatinib and HKI-272 are thought to require the inactive
conformation of EGFR for binding because of their additional
aniline substitutions.
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