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Figure 1.
Figure 1. Structure of the Trm8-Trm82 Complex
(A)
Cartoon representation of the Trm8-Trm82 complex. The
Trm8-specific insertions to the methyltransferase fold are
colored red. The α3 helix and AdoMet cofactor, not observable
in the complex but present in the free Trm8 structure, are
shown. The β4-αD loop has been modeled using the BsTrmB
structure as a reference.
(B and C) Surface representation
of the Trm8-Trm82 complex in the same orientation as (A). The
surface in (B) is colored in increasing shades of red reflecting
increasing residue conservation. The electrostatic potential in
(C) is colored on the surface of the protein from red (negative)
to blue (positive). Figures were generated using PyMOL (DeLano,
2002).
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