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Figure 1.
FIGURE 1. Sequence and structure of the p62 protein and its
UBA domain. Schematic representation of the p62 protein and its
domain structure is shown (A). The sequence of the C-terminal
UBA domain is shown expanded with the numbering from the
full-length protein shown (residues 387–436). The position of
the conserved Met-Gly-Phe-Ser loop is underlined; Gly^410 and
Gly^411 correspond to the double glycine insertion (B). The
secondary structure content of the UBA domain identified in the
unbound form by NMR is shown in C. NMR structure of the p62-UBA
domain shows the position of mutated residues associated with
Paget disease of bone (D), and a ribbon structure of the UBA
domain shows the packing of core hydrophobic residues Met^401,
Leu^417, Ala^427, and Ile^431 (E).
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