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Figure 1.
Fig. 1. Structure of human Robo1 Ig1–2. (A) Ribbon
diagram. The disulfide bridges are in yellow, and the box
indicates the region highlighted in B. (B) Residues involved in
interdomain contacts of the Ig1-Ig2 interface. (C) Ribbon
diagram of the two Ig1–2 crystal forms showing the hinge
movement of Ig2. (D) Sequence alignment of Ig1 domains of human
Robo1, -2, -3, and -4 and of the Ig2 domain of human Robo1.
Residue numbering is for Robo1 Ig1 (above) and Robo1 Ig2
(below). Slit2 D2-binding residues selected for mutagenesis are
marked with a star, and residues strictly conserved between the
Ig1 domain of human Robo1, -2, -3, and -4 are shown in red.
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