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Figure 1.
Figure 1. Overall Structure of the Mouse TLR4-MD-2 Complex
(A–C) Three views of the mouse TLR4-MD-2 complex are
shown in the diagrams. The N-terminal, central, and C-terminal
domains of TLR4 are colored in blue, cyan, and green,
respectively. The beta strands of MD-2 are shown in pink and
red, and the LRR modules of TLR4 are numbered.
(D) Closeup
view of mouse MD-2. Disulfide bridges are shown in yellow and
cysteines are labeled. Cys133 is not involved in the disulfide
bridge formation. The orientation of this view is the same as
for (C).
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