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Figure 1.
Fig. 1. The structure of the ligand-binding core of GluR
 2.
(A) Domain organization of the GluR 2 receptor subunit. The
architecture is similar to other glutamate receptors (AMPA,
kainate, and NMDA receptors), with an extracellular N terminus,
three transmembrane segments (M1, M2, and M3), a reentrant
membrane loop (P), and an intracellular C terminus. The
extracellular regions harbor the N-terminal domain (NTD) and the
ligand-binding core (D1 and D2). The red dot shows the
approximate position of the lurcher mutation (A654T). The
boundaries of the GluR 2–S1S2 construct are
indicated by scissors, and the dotted line represents the
Gly–Thr linker. (B) Representation of the twofold symmetric
dimer of GluR 2–S1S2 apo (in
yellow). The structure of GluR 2–S1S2 in complex
with D-serine has been superimposed onto GluR 2–S1S2
apo and is shown in red. D-serine is displayed as green spheres.
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