Figure 1.
(a) Two IL-15–IL-15R complexes
in the asymmetric unit of the P2[1]2[1]2 crystal form. One IL-15
molecule (magenta) forms a complex with one IL-15R molecule
(cyan), which then associates with another complex of IL-15
(blue) and IL-15R (red).
These two complexes have a noncrystallographic twofold
relationship. (b) Superposition of dimers of IL-15–IL15R complexes
from the P2[1]2[1]2 (red) and P2[1]2[1]2[1] (blue) crystals.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nat Immunol
(2007,
8,
1001-1007)
copyright 2007.
complexes
in the asymmetric unit of the P2[1]2[1]2 crystal form. One IL-15
molecule (magenta) forms a complex with one IL-15R