Figure 1.
(a) Chemical structures of N-methylpropargyl-K4 H3[1–21],
its covalent adduct with FAD, and the NaBH[4]-reduced adduct.
(b) Stereo view of the structure of the N-methylpropargyl-K4
H3[1–21]–FAD adduct in stick representation, overlaid with a
simulated-annealing composite-omit map contoured at 1.2 .
(c) Overall structure of LSD1–CoREST–H3. The FAD-H3 adduct
is shown in stick representation. All structural figures were
generated with PyMOL (http://pymol.sourceforge.net).
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nat Struct Biol
(2007,
14,
535-539)
copyright 2007.
.
(c) Overall structure of LSD1–CoREST–H3. The FAD-H3 adduct
is shown in stick representation. All structural figures were
generated with PyMOL (http://pymol.sourceforge.net).