Figure 1.
(a) Ribbon model of Kap 2
(pink), hnRNP M NLS (magenta) and the 2.5 F[o]
– F[c] map (blue). (b) NLSs of hnRNP M (magenta) and hnRNP A1
(2H4M; blue) upon superposition of Kap 2
residues 435–780. Regions of structural similarity are
highlighted in yellow. Structurally aligned NLS sequences, C
–C
distances
and inhibitor M9M sequence are shown. (c) Loss of Kap 2-binding
energy in alanine mutants of hnRNP A1 (ref.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nat Struct Biol
(2007,
14,
452-454)
copyright 2007.
2
(pink), hnRNP M NLS (magenta) and the 2.5 
F[o]
– F[c] map (blue). (b) NLSs of hnRNP M (magenta) and hnRNP A1
(2H4M; blue) upon superposition of Kap 
–C