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Figure 1.
Fig. 1. Overall structure of the pre-BCR. (A) Cartoon
representation of the pre-BCR complex with the Fab-like arm of
the pre-BCR that was crystallized (dashed box). (B) Ribbon
representation of the pre-BCR structure [dashed box in (A)].
Three protein chains are included in the model: VpreB (yellow),
 5 (magenta), and
HC (blue). Missing portions of the molecule are indicated with
residue numbers and dashed lines at the N terminus of 5
and the C terminus of VpreB. (C) Schematic representation of the
V-type Ig fold formed by VpreB and 5. ß
strands are designated by arrows labeled a to g. VpreB loops
that are homologous to Fab CDRs are labeled. The dashed
rectangle indicates the portion of the structure shown in (D).
The red line with "SS" indicates the intracellular domain
disulfide bond. (D) 2.7 Å electron density map (  [A]-weighted
2F[o] – F[c], where F[o] and F[c] are the observed and
calculated structure factors; contoured to 1.2 )
showing the a and f strands of VpreB and the g strand of 5.
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