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Figure 1.
Figure 1. The Imatinib-Binding Pocket
(A) Chemical
structure of imatinib.
(B) The imatinib-binding pocket in
Abl (PDB code 1OPJ) (Nagar et al., 2003). The Cα atoms of
residues that interact with imatinib are depicted as spheres.
Blue, residues that are invariant among Abl, c-Src, Lck, Hck,
PDGFR, and c-Kit; yellow, residues that are identical between
Abl and c-Src, but not between Abl and c-Kit or PDGFR; red,
residues unique to Abl.
(C) Sequence alignment of Abl,
c-Src, Hck, Lck, PDGFR, and c-Kit kinase domains. Residues that
are the same as in Abl are yellow. Residues that interact with
imatinib in the structure of Abl are in orange. Stars are color
coded according to the spheres in (B).
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