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Figure 1.
Figure 1. Poliovirus 3D^pol–GTP structure and picornaviral
finger-thumb interactions. (a) Front and (b) top views of the
3D^pol–GTP complex highlighting the various domains of the
polymerase. The thumb domain is blue and the palm is colored
grey with the conserved catalytic center colored in magenta. The
fingers domain can be subdivided into individual digits where
the index finger is shown in green, the middle finger in orange,
the ring finger in yellow, and the pinky finger in pink. The
buried N terminus is shown with a blue sphere and several of the
aromatic residues important for the inter-domain interaction
between the fingers and thumb domains (F30, F34 and W403) are
depicted with sticks. (c) Detailed view of homologous
interactions at the top of the three picornaviral polymerase
thumb domains (surface representation) to illustrate the
hydrophobic crevasse into which hydrophobic residues from the
index fingertip are inserted. Polymerases are from poliovirus
(PV^1), human rhinovirus (HRV^3), and foot-and-mouth disease
virus (FMDV^4).
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