Figure 1.
FIGURE 1. Structure and autophosphorylation of human Nek2.
A, schematic showing the major structural and functional
features Nek2A organization. Sites of autophosphorylation within
both the catalytic and C-terminal regions are shown. PP1c,
protein phosphatase 1c. B, a section of the 2F[o] - F[c]
electron density map around the SU11652 inhibitor, contoured at
1 .
C, structure of the Nek2 kinase domain-SU11652 complex. The N
and C lobes are colored blue and red, respectively, the hinge
region is highlighted in yellow, and the inhibitor is shown in
green. Regions of disorder in the structure are included as
dashed lines. D, phylogenetic tree showing the sequence
relationships between the eleven human Nek-family members.
The above figure is reprinted
by permission from the ASBMB:
J Biol Chem
(2007,
282,
6833-6842)
copyright 2007.
.
C, structure of the Nek2 kinase domain-SU11652 complex. The N
and C lobes are colored blue and red, respectively, the hinge
region is highlighted in yellow, and the inhibitor is shown in
green. Regions of disorder in the structure are included as
dashed lines. D, phylogenetic tree showing the sequence
relationships between the eleven human Nek-family members.