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Figure 1.
Figure 1. Inhibition of SARS-CoV M^pro by the aza-peptide
epoxides (APEs) synthesized for our study,
Cbz-Leu-Phe-AGln-EP-CooEt. The epoxide carbon atoms are numbered
and their stereochemistry is omitted for simplicity. The
proposed mechanism for the irreversible inhibition of clan CD
cysteine peptidases by APEs is indicated by arrows. In the
inhibition of M^pro, route I was adopted. Cbz, the
benzyloxycarbonyl group; AGln, aza-glutamine; EP, epoxide;
COOEt, ethyl ester.
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