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Figure 1.
Figure 1. The overall architecture of the KChIP1–Kv4.3N
complex. All panels have the same color codes, with some
secondary structural elements labeled specifically. (a)
Schematic representation of the complex structure in one
asymmetric unit. Two KChIP1 and two Kv4.3 molecules are shown in
orange and blue, respectively. (b) The 4:4 complex of
KChIP1-Kv4.3N shown was generated from the complex in a through
symmetric operations. The complex in this panel has the same
size as the one shown in Figure 6a. (c) One KChIP1 molecule
interacts simultaneously with two Kv4.3Ns. In the complex, each
KChIP1 molecule not only binds to the N-terminal peptide of one
Kv4.3 but also interacts with an adjacent Kv4.3 T1 domain,
forming two contact interfaces; the first interface is shown in
the red frame and second interface is shown in the blue frame.
(d) A cartoon of the KChIP1-Kv4.3N complex in 4:4 showing the
clamping effect of KChIP1 molecule on the tetramer of Kv4.3.
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