Figure 1.
FIGURE 1. Switching of the hairpin loop in response
to nucleotide incorporation opposite a lesion. A, the closed
ternary complex of RB69 gp43 trapped with an incoming dTTP
opposite a templating A (PDB code 1IG9 (17)). The 5'-end of the
template DNA (gray) stacks against Trp-574 (gold), and the hairpin
is in an up position. B, an open binary complex of RB69 gp43
after successful incorporation of an A opposite a furan (PDB
code 1RV2, chain C (15)). In this structure the 5'-end of the
template is sandwiched between Phe-359 (purple) and the hairpin,
which is in a down position.
The above figure is reprinted
by permission from the ASBMB:
J Biol Chem
(2007,
282,
1432-1444)
copyright 2007.
hairpin loop in response
to nucleotide incorporation opposite a lesion. A, the closed
ternary complex of RB69 gp43 trapped with an incoming dTTP
opposite a templating A (PDB code 1IG9 (17)). The 5'-end of the
template DNA (gray) stacks against Trp-574 (gold), and the