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Figure 1.
Fig. 1. (A) The molecular structure of T-fluorescein. (B)
An overview of the UvrB molecule (represented as a molecular
surface) showing the relative locations of the pentathymine
molecule (cyan), the conserved β-hairpin (light green), domains
1a (yellow), 1b (grey), 2 (green) and 3 (pink). (C) A magnified
view of the pentathymine molecule identifying the position of
the T-fluorescein adducted nucleotide, TF3 (magenta), together
with associated F[o] − F[c] omit map density contoured at
2.5σ. The location of the lesion reveals that the damage is
extruded away from the UvrB molecule. PT5 denotes the 5′
phosphate group of T5 that is the only visible moiety of this
nucleotide. All figures were generated using Pymol (Delano
Scientific, www.pymol.org).
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