Figure 1 - full size

Figure 1. Figure 1. Effects of the two mutations (Lys103Asn and Tyr181Cys) on the structure of unliganded HIV-1 RT. (a) A stereo view of the NNIBP region of the double mutant RT/ATP structure. The composite simulated annealing omit map (2|F[o]|–|F[c]|) electron density (cyan) contoured at 1.2σ defines the coordination of a Na ion at the NNIBP region; OW1 and OW2 are two water molecules. (b) The NNIBP region of the double mutant (Lys103Asn/Tyr181Cys) HIV-1 RT. The mutated amino acids have altered interactions with the surrounding amino acids. (c) The NNIBP region of the wild type unliganded HIV-1 RT structure.^13

The above figure is reprinted by permission from Elsevier: J Mol Biol (2007, 365, 77-89) copyright 2007.