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Figure 1.
Figure 1. Crystal Structure of C2a
(A) Schematic
representation of domain topology of C2 and formation of the C3
convertase.
(B) Electron density (2mF[o] − DF[c], φ[c])
of the glycan attached to Asn-447; Asn-447-GlcNac-GlcNac-Man are
shown.
(C) Stereo ribbon representation of the C2a-Mn^2+
structure; the catalytic triad (blue) in the SP domain (orange),
the linker region (light blue) between the SP and VWA domains
(green; its N-terminal residue is indicated by a green sphere),
the manganese ion (pink) bound at the MIDAS motif, and the six
glycosylation sites (gray) are shown.
(D) Overlay of C2a
(black) and Bb (1rrk, green) (Ponnuraj et al., 2004)
superimposed on the SP domains; the different positions of the
α7 helix in the VWA domains are indicated.
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