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Figure 1.
Figure 1: Crystal structure of the DDB1–CUL4A–ROC1 ubiquitin
ligase complex hijacked by the V protein of simian virus 5.
a, b, Two orthogonal views of the complex structure are shown in
ribbon diagram. DDB1, CUL4A, ROC1 and SV5-V are coloured in
blue, green, red and magenta, respectively. The BPB domain of
DDB1 is coloured in cyan. The zinc atoms in ROC1 and SV5-V are
represented as orange spheres. A previously identified
STAT2-binding site^17 of the viral protein, as well as the four
domains of DDB1, are indicated.
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