Figure 1.
Figure 1. Crystal structure of WDR5 bound to the N terminus of
histone H3. (a) Two orthogonal views of the secondary
structure of WDR5 with the -propeller
blades and the N and C termini labeled. The distorted sixth -propeller
is highlighted in green, and the carbon atoms of the histone H3
peptide are rendered in yellow. (b) Electrostatic surface of
WDR5 showing the histone H3 binding cleft (blue and red denote
positively and negatively charged regions, respectively). The
histone H3 peptide is shown as in a.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nat Struct Mol Biol
(2006,
13,
698-703)
copyright 2006.
-propeller
blades and the N and C termini labeled. The distorted sixth