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Figure 1.
Schematic illustration of the role of AGM1 in the
biosynthetic pathway of UDP-GlcNAc. In eukaryotes, UDP-GlcNAc is
synthesized from fructose 6-phosphate by four successive
reactions: (i) the conversion of Fru-6-P into GlcN-6-P; (ii) the
acetylation of GlcN-6-P into GlcNAc-6-P; (iii) the
interconversion of GlcNAc-6-P and GlcNAc-1-P; and (iv) the
uridylation of GlcNAc-1-P into UDP-GlcNAc. AGM1 is catalyzed in
step iii.In prokaryotes, the intramolecular phosphoryl transfer
(step iii) occurs before acetylation (step ii), and GlcN-1-P is
generated as the intermediate.
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