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Figure 1.
Figure 1. (a) Schematic of the domain structure of CDPK.
The regulatory apparatus is comprised of the Junction region (J)
and the calmodulin-like domain (CaM-LD). (b) Ribbon diagram of
the crystal structure of the regulatory apparatus of CDPK
showing the homodimeric organization observed. The two molecules
are coloured in red and blue, respectively. The J region of each
monomer depicted in a darker colour is observed interacting with
the partner molecule in a domain swap interaction. The inset
depicts these interactions schematically. (c) Overlay of the
amino-terminal and carboxyl-terminal calcium-binding sub-domains
of the CaM-LD (N-lobe and C-lobe, respectively). The
root-mean-square deviation (RMSD) of C^α atoms for the overlay
is 0.9 Å. The models are complete except for residues
428–432, 556–562, 588–591 from protomer A and residues
428–432, 551–566, 588–591 from protomer B.
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