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Figure 1.
FIGURE 1. Modeling of Inhibitor 1 into the PTP1B active
site. The structure of Inhibitor 1 is shown in the inset. The
active-site nucleophile Cys^215 in the PTP loop (pink) is shown
along with Phe^182 in the WPD loop (green). Inhibitor 1 sits in
the active site with the phosphonate (red) interacting with the
PTP loop, and the difluoro group is within van der Waals
distance of the phenyl side chain of Phe^182.
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