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Figure 1.
X-ray crystal structure of NS3h bound to a 16-mer poly(dU)
substrate. Three molecules of NS3h are found in the asymmetric
unit, and two of the helicase monomers, chain A (red) and chain
B (blue), are bound to a single DNA substrate molecule (aqua).
The third molecule of the asymmetric unit (chain C, shown in
green) is bound to a separate strand of nucleic acid. The DNA
passes across the face of chain A, emerging between domains 2
and 3, where it enters the binding site of chain B.
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