Figure 1.
Figure 1. Crystal structure of unliganded hGHR ECD. (a) A
ribbon diagram of the unliganded hGHR extracellular domain.
Highlighted areas are the two hormone binding residues Trp104
and Trp169; in purple is the hormone binding region, in magenta
is the flexible linker, and in light blue and green is the
activation lock-and-key region ('dimerization domain'). (b)
Stereo superimposition of C traces
of hGHR from different crystal structures: molecule A in
unliganded structure (blue), molecule B in unliganded structure
(pink), 1:1 complex (green, PDB entry 1A22 chain B), 2:1 complex
(purple, PDB entry 1HGW chain B), 2:1 complex (red, PDB entry
1HGW chain C).
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nat Struct Mol Biol
(2005,
12,
814-821)
copyright 2005.
traces
of hGHR from different crystal structures: molecule A in
unliganded structure (blue), molecule B in unliganded structure
(pink), 1:1 complex (green, PDB entry 1A22 chain B), 2:1 complex
(purple, PDB entry 1HGW chain B), 2:1 complex (red, PDB entry
1HGW chain C).