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Figure 1.
Figure 1. (A) Simplified schematic diagram of the
Notch-mediated transcriptional "switch." NICD is composed of a
membrane proximal RAM domain (yellow), seven ARs (red), and
C-terminal PEST, OPA domains (navy). Binding of NICD to CSL
displaces transcriptional repressors (SMRT, HDAC, CIR) and leads
to recruitment of transcriptional activators MAM and HAT. (B) A
2.2 Å crystal structure of mouse Notch1 ARs 3  -7. There are
two molecules in the asymmetric unit of the crystal. Repeats 3
-7 of molecule
A are colored red, yellow, green, brown, and cyan, respectively.
Repeats of molecule B are colored gray. (C) Structural overlay
of partial ANK domain of mouse Notch-1 with ARs is color coded
as in B and the dANK domain of the Drosophila Notch receptor is
shown in a gray transparent worm representation.
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