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Figure 1.
Fig. 1. Ligand-binding cores of the three classes of
iGluRs. Cartoon representations of the overall structures of the
AMPA receptor GluR2-S1S2J (MolB, pdb code 1FTJ; left figure),
the kainate receptor GluR5-S1S2 (MolB; middle figure) and the
NMDA receptor NR1-S1S2 (MolA, pdb code 1PB7; right figure).
Domain D1 (primarily composed of S1 residues) is colored cyan
and D2 (primarily composed of S2 residues) is colored brown.
GluR2-S1S2J and GluR5-S1S2 were crystallized in the presence of
(S)-glutamate, whereas NR1 was crystallized in complex with
(S)-glycine. The ligands are shown in ball-and-stick
representation.
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