|
Figure 1.
Figure 1. Structure of TCR 172.10 in Complex with
I-A^u/MBP1-11(A) Ribbon representation of the complex including
172.10Vα (red), 172.10Vβ (blue), I-A^u (green), and MBP
residues 1–8 (yellow). The CDR loops from 172.10 are colored
as follows: CDR1α (magenta), CDR2α (pink), CDR3α (red),
CDR1β (maroon), CDR2β (cyan), and CDR3β (blue).(B) Side view
(turned 90° from [A]) of the complex. MBP peptide is shown
as a transparent molecular surface (yellow) with ball-and-stick
representations of amino acids inside, including the leader
peptide (gray). The β1 helix from I-A^u is in the front, and
the α1 helix is behind the peptide.(C) 172.10 footprint showing
docking orientation on I-A^u/MBP1-11. Peptide-MHC is shown as a
green surface (peptide in yellow, leader residues in gray), and
the 172.10 CDR loops are drawn as tubes and labeled. This and
all subsequent figures were produced with PyMol (Delano, 2002).
|
