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Figure 1.
Figure 1 HisA and TrpF catalyse similar reactions in histidine
and tryptophan biosynthesis. HisA and TrpF catalyse the
isomerizations of the aminoaldoses ProFAR and PRA to the
aminoketoses
N'-((5'-phosphoribulosyl)formimino)-5-aminoimidazole-4-carboxamide
ribonucleotide (PRFAR) and
1-(o-carboxyphenylamino)-1-deoxyribulose 5-phosphate (CdRP). The
PriA protein catalyses both reactions in Streptomyces coelicolor
and Mycobacterium tuberculosis. These organisms lack a trpf gene.
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