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Figure 1.
Figure 1. Stereoview of an overlay of mTREM-1 and
comparison with other related immunoglobulin folds. (a) A ribbon
diagram of the mTREM-1 structure determined here. (b) The
mTREM-1 structure (cyan) has the expected V-set Ig domain fold
seen in immunoglobulins (light blue, PDB code 1mfa), T-cell
receptors (green, PDB code 1tcr) and the human natural killer
cell activating receptor, NKp44 (red, PDB code 1hkf). The groove
formed by b-hairpins formed by strands C-C' and F-G is more
pronounced than those in IgG, TCR or activating receptor Ig
domains. Furthermore, mTREM-1 lacks the disulfide bridge
(C37-C45) present only in NKp44. (c) Stereoview of a C^a trace
of the previously published hTREM-1 structures from our
laboratory (blue, 1smo),15 Radeav et al.14 (1q8m, green), and
our mTREM-1 structure (red). The orientation mTREM-1 overlays in
b) and c) are identical with that in a). Disulfides are labeled
yellow (for carbon) and green (for sulfur). This Figure, and all
subsequent ribbon diagrams, were made with Bobscript22 and
Raster3D.23
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