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Figure 1.
Figure 1. Structure of β2-Chimaerin(A) Refined model of
β2-chimaerin in the vicinity of Gln32 superimposed on the
solvent-modified single anomalous dispersion (SAD) Fourier
synthesis.(B) Overall structure of β2-chimaerin. The domains
red (SH2), blue (C1), green (RacGAP), and grey (linkers).(C)
Structure of the SH2 domain (red) overlaid on the SH2 domain of
Src (cyan) and showing the internal phosphotyrosine-containing
sequence in Src in a stick representation.(D) Structure of the
C1 domain (blue) overlaid on the C1B domain of PKCδ (cyan) and
showing phorbol ester as bound to the the PKCδ-C1B.(E)
Structure of the RacGAP domain (green) overlaid on the RhoGAP
domain of p50RhoGAP (grey), showing the bound Cdc42 protein
(yellow) in complex with GDP and AlF[x]^− (stick model).(F)
Linker regions are shown in a worm represenation, with the rest
of β2-chimaerin shown in a space-filling representation,
oriented and colored as in (B).
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