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Figure 1.
Figure 1. (a) Ribbon representation of the structure of
PfTIM monomer. Trp11 (blue) and Trp168 (green) are shown in
sticks. (b) and (c) Hydrogen bonding interactions of the
N-terminal hinge residues, Pro166, Leu167 and Trp168 in the open
and closed forms of loop6, respectively. The Figures were
generated using MOLSCRIPT39 and rendered using Raster3D.40 (d)
Chemical structures of the substrates and various ligands of
TIM; dihydroxyacetone phosphate (DHAP),
glyceraldehyde-3-phosphate (GAP), 2-phosphoglycolate (PGA),
2-phosphoglycerate (2PG), glycerol-3-phosphate (G-3P) and
glycerol-2-phosphate (G-2P).
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