Figure 1.
Figure 1 Crystal structure of the RAR LBD
-TTNPB complex reveals an additional cavity in the RAR LBP.
(A) Electron density map of TTNPB in its pocket. 2F[o] -F[c] map
at 2.1 Å resolution contoured at 1 .
The three isotype-specific residues (A[225], I[263] and V[388])
and residues anchoring the carboxylate (R[269] and S[280]) are
indicated. Illustration by PYMOL. (B) Superposition of the
holo-RAR -TTNPB
(yellow) and RAR -9-cis
RA (blue) LBDs. Illustration by SETOR. (C) Superposition of
TTNPB -RAR (blue)
and 9-cis RA -RAR (grey)
LBDs. The isotype-specific residues are shown in cyan (RAR )
and orange (RAR )
and TTNPB in yellow. The carboxylate anchoring residues are
illustrated as ball-and-sticks. H bonds are represented as
dashed lines. The figure was prepared by MOLSCRIPT and RASTER3D.
(D) Superimposition of RAR (blue)
and RAR (grey)
LBPs. The arrow points to the additional cavity in RAR .
The above figure is reprinted
from an Open Access publication published by Macmillan Publishers Ltd:
EMBO Rep
(2004,
5,
877-882)
copyright 2004.
LBD
-TTNPB complex reveals an additional cavity in the RAR 
.
The three isotype-specific residues (A[225], I[263] and V[388])
and residues anchoring the carboxylate (R[269] and S[280]) are
indicated. Illustration by PYMOL. (B) Superposition of the
holo-RAR 
-9-cis
RA (blue) LBDs. Illustration by SETOR. (C) Superposition of
TTNPB -RAR