|
Figure 1.
Fig. 1. Schematic representation of the overall IgG and IgNAR
architectures. (A) A conventional IgG is composed of two H
chains (blue) and two L chains (yellow) that assemble to form
one Fc and two Fab regions or superdomains. The H chain has
three C domains (C[H]1, C[H]2, and C[H]3) and one V domain
(V[H]), whereas the L chain has one C domain (C[L]) and one V
domain (V[L]). The V region is made up of two immunoglobulin
domains (V[H] and V[L]). (B) IgNAR only two H chains, each
consisting of one V and five C domains, where the V domain is
unpaired and constitutes a single-binding module. The IgG and
the IgNAR domains are represented by their harmonic surfaces
generated from atomic coordinates (27); the IgNAR C domains are
represented by ovals because their structures are unknown.
|
