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Figure 1.
Figure 1. Crystal structure of the extracellular domain of
PknD. (A) Stereo view of the electron density map (2F[o] -F[c])
of monoclinic crystal form. Electron density is displayed
surrounding one of the invariant prolines in the "cup" and the
exposed Tyr511. (B) The PknD sensor domain forms a six-bladed b
propeller. Four strands constitute each of the six blades. The
numbers around the periphery indicate the blade number, with the
full blade nearest the N terminus labeled 1. The "latch" formed
by the N and C termini is boxed. The 3-4 loop in blade 1 is
disordered. The b propeller forms an approximate cylinder with a
radius of 40 Å and a height of 35 Å. (C) Electron
density (2F[o] -F[c]) showing rings of ordered water molecules
stacked in the central channel of the PknD b propeller. The
central pseudo-symmetry axis runs vertically through the center
of the rings.
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