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Figure 1.
Fig. 1. Structure of NGF complexed with p75. (A) p75 binds
along one side of the NGF homodimer. Backbone representation of
NGF monomer A is colored green; monomer B, blue; and p75,
purple. Disulfide bonds are shown as green sticks. Other figures
have the same coloring scheme. (B) p75 binds across the NGF
dimerization interface. Front view, with a horizontal rotation
of 90° from the orientation of the complex seen in (A) with
NGF depicted as surface and p75 as tube. (C) p75 uses the
opposite side as TNFR-SF members for ligand binding, but both
bind within their ligands' oligomer interfaces. One copy of
TNF-R1 from the TNF-ß-TNF-R1 complex (16) is superimposed
with p75 from the NGF-p75 complex. The two receptors used in
superimposition are depicted in main-chain traces, and the other
molecules in space-filling format.
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