Figure 1.
Figure 1. Comparison of the chemical structures of tenofovir,
dTMP and the NRTIs 3TCMP and AZTMP. The azido group of AZTMP
and the sulfur of the L- -oxathialone
ring of 3TCMP protrude through the envelope of normal substrates
and can serve as handles for the development of NRTI resistance.
The above figure is reprinted
by permission from Macmillan Publishers Ltd:
Nat Struct Mol Biol
(2004,
11,
469-474)
copyright 2004.
-oxathialone
ring of 3TCMP protrude through the envelope of normal substrates
and can serve as handles for the development of NRTI resistance.